• Jean-Baptiste Roullet | on 2nd Mar
    It is well established that nutrition impacts the epigenome and risk for diseases. It is also known that the epigenome impacts drug metabolism and activity. However, how diet-induced epigenetic modifications of genes involved in drug metabolism and activity contributes t ...

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  • Until recently, dietary constituents were assumed to be simply absorbed or metabolized by our human cells. However, we now understand that microbial communities resident in the human gastrointestinal tract play major roles not only in allowing us to efficiently harvest e ...

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  • Charlene Compher | on 3rd Mar
    Our current dietary guidelines were established on research obtained prior to evaluation of the impact of nutrigenomics, metabolomics, and gut microbiomic constraints. Analysis of comprehensive data streams in representative samples could greatly enhance our success at p ...

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  • Clement Adebamowo | on 4th Mar
    Understanding associations between long term dietary intakes and complex diseases remains a challenge in nutrition epidemiology. Research that identifies genomic, epigenomic, microbiomic, proteomic, lipidomic markers of long term dietary intakes should be a priority tran ...

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  • Catharine Ross | on 3rd Mar
    1. Remove barriers to lifespan and multigenerational studies by funding across NICHD, NIDDK, NIA and ODS so that key questions of pre-pregnancy to birth, to postnatal life, to aging (and chronic diseases) can be addressed. Facilitate key research projects that cover a sp ...

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  • Methods of dietary assessment are difficult, time consuming, and not well suited for clinical practice. Yet, having an understanding of an individual's eating habits is critical to studying obesity, diabetes, cardiovascular disease, cancer, and many other conditions. Mu ...

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  • Growing evidence links consumption of highly palatable foods to the onset of hypothalamic neuron injury and both micro- and astrogliosis in an area closely tied to the control of energy homeostasis (the arcuate nucleus). Activation of these glial cells appears to be req ...

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  • Diets provide not only macronutrients containing energy, but also micronutrients with regulatory roles. The roles of micronutrients in the regulation and management of body weight and chronic metabolic diseases have not been clearly defined.
  • Maternally-derived environmental stressors (drugs, pollutants, etc) can cause long-term adverse outcomes in their offspring, and possibly in subsequent generations. Developmental exposure to these chemical stressors occurs in the context of maternal diet which can contai ...

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  • Metabolomics is rapidly emerging as an experimental approach in the field of nutrition science to study food components and their metabolites in body fluids and biological tissues, microbiome-related metabolisms and their complex interaction with diet, and the physiologi ...

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  • Many lines of evidence have indicated that we are indeed, at least in part, what we eat. However, our current understanding about the interactions between genetic alleles and nutrients intake is still largely insufficient. Beyond genetic effects, epigenomic factors and g ...

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  • Understanding the relationship between body weight/BMI and muscle mass/quality to treatment toxicity, progression and survival is complex and is not known among cancer patients undergoing treatment. Current nutrition screening practice focuses on weight status and weigh ...

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